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Methanol and acetone extracts of the twigs were shown to be safe in male Swiss albino mice at a dose of 849–900 mg/kg. A methanolic root extracts showed promising selective inhibition of HIV-1 replication. Extracts from leaves and stem bark showed significant inhibitory activities against acetylcholinesterase and butyrylcholinesterase. An acetone leaf extract showed significant anthelmintic activity against the gastrointestinal sheep nematode ''Haemonchus contortus''. A methanolic leaf extract showed moderate antiplasmodial activity against the multi-resistant strain (W2) of ''Plasmodium falciparum''. The extracts tested also displayed low levels of cytotoxicity against K562S cells.

Several other ''Combretum'' species have similar traditional medicinal uses as ''Combretum molle'', and showed significant antimicrobial properties.