''Begonia'' comprises about 1400 species, with about 160 in tropical Africa. ''Begonia macrocarpa'' belongs to section ''Filicibegonia'' and is closely related to ''Begonia auriculata'' Hook.f., which usually has larger leaves and stipules and a longer peduncle, and is endemic to Gabon.
=== Other ''Begonia'' ===In Central Africa several other ''Begonia'' species are eaten as a vegetable in a similar way to ''Begonia macrocarpa'', e.g. ''[[Begonia elatostemmoides]]'' Hook.f., ''[[Begonia eminii]]'' Warb., ''[[Begonia fusialata]]'' Warb., ''[[Begonia hirsutula]]'' Hook.f., ''[[Begonia komoensis]]'' Irmsch., ''[[Begonia sciaphila]]'' Gilg ex Engl., ''[[Begonia scutifolia]]'' Hook.f. and ''[[Begonia sessilifolia]]'' Hook.f.
''Begonia macrocarpa'' occurs in primary and secondary forest, especially along roads and rivers, up to 1000 m altitude.