The range of ''Calycobolus africanus'' overlaps with that of ''Calycobolus heudelotii''. In Côte d’Ivoire a decoction of the leaves is taken for lower back pain, and a bath in a decoction of the stem, as well as applying a paste of leaves and stems have aphrodisiac effects. The leaves are eaten or taken in an enema to cure fever. In Cameroon a root decoction is drunk to overcome sexual dysfunction. The flexible stems of ''Calycobolus africanus'' are used in Côte d’Ivoire as binding material in construction and the thick woody stems are used to make household goods.
=== ''Calycobolus parviflorus'' ===
''Calycobolus parviflorus'' occurs in Sierra Leone, Liberia, Côte d’Ivoire and Ghana. In Côte d’Ivoire the powdered bark is taken with food by pregnant women to sooth stomach-ache.